d representative immunohistochemistry images (Human Protein Atlas)
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D Representative Immunohistochemistry Images, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Images
1) Product Images from "KNTC1 initiates a KNTC1/E2F8/MYC positive feedback loop to facilitate tumorigenesis and enhance chemoresistance in bladder cancer"
Article Title: KNTC1 initiates a KNTC1/E2F8/MYC positive feedback loop to facilitate tumorigenesis and enhance chemoresistance in bladder cancer
Journal: Journal of Experimental & Clinical Cancer Research : CR
doi: 10.1186/s13046-026-03651-4
Figure Legend Snippet: KNTC1 upregulation in BLCA associates with poor patient prognosis. A Venn diagram showing 4 potential oncogenes which cross-analyzed by three GEO databases ( GSE133624 , GSE188715 , GSE231383 , GSE37815 ) with our own sequencing data. B and C Analysis of KNTC1 mRNA expression in normal bladder tissues and BLCA was performed using datasets from TCGA BLCA and GEO ( GSE13507 , GSE133624 , GSE188715 ). D Representative immunohistochemistry images for normal bladder tissues and BLCA are shown from The Human Protein Atlas (HPA) database. E The expression of KNTC1 was detected by immunohistochemistry (IHC) in BLCA tissues and adjacent non-cancerous tissues. F A quantitative analysis of IHC scores was performed to determine the expression of KNTC1 in 50 pairs of clinical BLCA specimens we collected. G The protein expression level of KNTC1 was examined by western blotting in our collected BLCA tissues and paired adjacent normal tissues. H Kaplan-Meier overall survival (OS) curves for BLCA patients with high or low KNTC1 mRNA expression from GEO datasets ( GSE216037 , GSE19432 ). I Schematic diagram of subcutaneous tumor model establishment and treatment. J The mRNA level of KNTC1 was determined in sh-KNTC1 UMUC3 cells by RT-qPCR assay. K Representative images of subcutaneous xenograft tumors ( n = 5 for each group). L Analysis of the tumour weight of the xenografts in each group. M Growth curves of the subcutaneous xenografts in each group. N Representative HE staining images (Scale bar = 200 µm) and IHC staining images (Scale bar = 50 µm) of Ki67 were presented in sh-Ctrl or sh-KNTC1 UMUC3 xenograft nude mice tissues. ns, no significance; * P < 0.05; ** P < 0.01; *** P < 0.001
Techniques Used: Sequencing, Expressing, Immunohistochemistry, Western Blot, Quantitative RT-PCR, Staining